Grasset N, Raffoul W, Bigliardi P
Service de chirurgie expérimentale et chirurgie pédiatrique, CHUV, 1011 Lausanne.
Rev Med Suisse. 2010 Feb 17;6(236):354-7.
Wound healing is a complex process involving several cell types (keratinocytes, fibroblasts, endothelial cells, etc.) as well as many growth factors (PDGF, TGF-betas, FGFs, VEGF, etc.). It can be challenging when wounds are deep or very large (third degree burn, ulceration after cutaneous tumor resection) or in presence of peripheral vascular disease, metabolic disturbances or peripheral neuropathy (chronic vascular or diabetic wounds). In order to promote skin regeneration, numerous bioactive dressings combining cells, matrices and growth factors are available on the market. This article provides a general overview of the various product categories and presents their main indications. The principal axes of the biomedical research in this area are also discussed.
伤口愈合是一个复杂的过程,涉及多种细胞类型(角质形成细胞、成纤维细胞、内皮细胞等)以及许多生长因子(血小板衍生生长因子、转化生长因子β、成纤维细胞生长因子、血管内皮生长因子等)。当伤口较深或非常大(三度烧伤、皮肤肿瘤切除后的溃疡),或存在周围血管疾病、代谢紊乱或周围神经病变(慢性血管性或糖尿病性伤口)时,伤口愈合可能具有挑战性。为了促进皮肤再生,市场上有许多结合了细胞、基质和生长因子的生物活性敷料。本文概述了各类产品,并介绍了它们的主要适应症。还讨论了该领域生物医学研究的主要方向。