Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Sos. Berceni, 10, R-041914, Bucharest, Romania.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):657-63. doi: 10.1016/j.pnpbp.2010.03.008. Epub 2010 Mar 15.
The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations.
We investigated the association between the G72/G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/G30 with lifetime psychosis and in particular with persecutory delusions in BPI patients.
Fourteen G72/G30-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders. Statistical analysis was performed with FAMHAP and HAPLOVIEW-v3.32. The significance level of the results was corrected through permutations in 100,000 simulations.
None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. When confining the psychotic phenotype to persecutory delusions, we observed trends to association for SNPs previously associated with schizophrenia and persecutory delusions in BPI [M21 (P=0.080); M22 (P=0.092; P=0.042 under dominant transmission model); M24 (P=0.092)]. Four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), and rs2391191 (M15, non-synonymous) (P=0.043)]. After correction through permutations, the haploblock GA including M14 and M15 showed a trend to association with BPI (P=0.0524; OR=1.82) in the non-psychotic BPI subgroup.
We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients. The results represent a first partial replication of two studies: Williams et al. (2006) and Schulze et al. (2005). The results have just a suggestive value since the Bonferroni correction for multiple testing was not applied.
G72/G30 基因是精神分裂症和双相情感障碍共同的常见基因之一。自该基因复合物发现以来，不同人群的研究在这两种疾病中均产生了有争议的结果。
我们研究了 G72/G30 基因与罗马尼亚人群中双相情感障碍 I 型（BPI）之间的关联，特别关注 G72/G30 与 BPI 患者的终生精神病，特别是被害妄想之间的关联。
对 198 名 BPI 患者和 180 名经筛选的无精神障碍对照者进行了 14 个 G72/G30-SNP 基因分型，这些对照者被筛查出有精神障碍。使用 FAMHAP 和 HAPLOVIEW-v3.32 进行统计分析。通过 100,000 次模拟进行随机排列，对结果的显著性水平进行校正。
在我们的总患者样本中，没有一个 SNP 与 BPI 的整体诊断相关，也与精神病性 BPI 亚型无关。当将精神病性表型局限于被害妄想时，我们观察到与之前在 BPI 中与精神分裂症和被害妄想相关的 SNP 存在关联的趋势[M21（P=0.080）；M22（P=0.092；在显性遗传模型下 P=0.042）；M24（P=0.092）]。在非精神病性 BPI 亚组中，有 4 个 SNP 达到了名义上的显著水平[rs3916965（M12）（P=0.044），rs1935057（P=0.037），rs3916967（M14）（P=0.043）和 rs2391191（M15，非同义）（P=0.043）]。经过随机排列校正后，包含 M14 和 M15 的 GA 单倍型在非精神病性 BPI 亚组中显示出与 BPI 相关的趋势（P=0.0524；OR=1.82）。
我们报告了不同 G72/G30-SNP 与罗马尼亚 BPI 患者非精神病性情绪发作和被害妄想之间的潜在关联。该结果代表了两项研究的首次部分复制：Williams 等人（2006 年）和 Schulze 等人（2005 年）。由于未应用多重检验的 Bonferroni 校正，因此该结果仅具有提示性价值。
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