Department of Neurology and Waisman Center, University of Wisconsin Madison, Wisconsin, USA.
Epilepsy Curr. 2010 Mar;10(2):42-6. doi: 10.1111/j.1535-7511.2009.01350.x.
Antiepileptic drugs (AEDs) target ion channels and neurotransmitter systems in the brain; these same targets are responsible for regulation of processes essential for brain development. In this review, experimental findings on adverse effects of AEDs in the developing mammalian brain will be presented, including interference with physiological apoptotic cell death, cell proliferation and migration, neurogenesis, axonal arborization, synaptogenesis, and synaptic plasticity.
抗癫痫药物 (AEDs) 作用于大脑中的离子通道和神经递质系统;这些相同的靶点负责调节大脑发育所必需的过程。在这篇综述中,将介绍 AEDs 在发育中的哺乳动物大脑中的不良反应的实验发现,包括干扰生理性细胞凋亡、细胞增殖和迁移、神经发生、轴突分支、突触形成和突触可塑性。