来那度胺成功治疗泛发性坏死性黄色肉芽肿

Generalized necrobiotic xanthogranuloma successfully treated with lenalidomide.

作者信息

Silapunt Sirunya, Chon Susan Y

机构信息

Department of Dermatology, University of Texas Medical School at Houston, Houston, TX, USA.

出版信息

J Drugs Dermatol. 2010 Mar;9(3):273-6.

PMID:20232591

Abstract

Necrobiotic xanthogranuloma (NXG) presents a therapeutic challenge to clinicians. Generalized NXG has limited treatment options. A patient presented to the authors with generalized NXG associated with monoclonal gammopathy of unknown significance (MGUS), a plasma cell dyscrasia considered to be a precursor to multiple myeloma. The patient was treated with lenalidomide, a derivative of thalidomide with efficacy in treatment of multiple myeloma. Resolution of paraproteinemia was associated with resolution of NXG.

摘要

坏死性黄色肉芽肿（NXG）给临床医生带来了治疗挑战。全身性NXG的治疗选择有限。一位患者因全身性NXG伴意义未明的单克隆丙种球蛋白病（MGUS）就诊于作者处，MGUS是一种浆细胞发育异常疾病，被认为是多发性骨髓瘤的前驱疾病。该患者接受了来那度胺治疗，来那度胺是沙利度胺的衍生物，对治疗多发性骨髓瘤有效。副蛋白血症的缓解与NXG的缓解相关。