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Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.
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On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
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Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J Biol Chem. 2012 Aug 10;287(33):27275-89. doi: 10.1074/jbc.M112.364125. Epub 2012 Jun 3.
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Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
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Regulation of MLL1 H3K4 methyltransferase activity by its core components.
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Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes.
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RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
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Defined Human Leukemic CD34+ Liquid Cultures to Study HDAC/Transcriptional Repressor Complexes.
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Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site.
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Clinical Utility of a Unique Genome-Wide DNA Methylation Signature for -Related Syndrome.
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本文引用的文献

1
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
FEBS J. 2010 Apr;277(8):1790-804. doi: 10.1111/j.1742-4658.2010.07606.x. Epub 2010 Mar 4.
2
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human.
FEBS J. 2010 Apr;277(8):1805-21. doi: 10.1111/j.1742-4658.2010.07607.x. Epub 2010 Mar 4.
3
Mixed lineage leukemia: roles in human malignancies and potential therapy.
FEBS J. 2010 Apr;277(8):1822-31. doi: 10.1111/j.1742-4658.2010.07608.x. Epub 2010 Mar 4.
4
WDR5, a complexed protein.
Nat Struct Mol Biol. 2009 Jul;16(7):678-80. doi: 10.1038/nsmb0709-678.
5
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25.
7
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Nat Struct Mol Biol. 2009 Mar;16(3):312-7. doi: 10.1038/nsmb.1560. Epub 2009 Feb 15.
9
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.
J Biol Chem. 2008 Dec 12;283(50):35258-64. doi: 10.1074/jbc.M806900200. Epub 2008 Oct 7.
10
Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
J Biol Chem. 2008 Nov 21;283(47):32158-61. doi: 10.1074/jbc.C800164200. Epub 2008 Oct 1.

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