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促肾上腺皮质激素和氢化可的松对脑结构功能状态及相互作用的影响

[Effect of ACTH and hydrocortisone on the functional state and interaction of brain structures].

作者信息

Sever'ianova L A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Jan;64(1):10-7.

PMID:202514
Abstract

In chronic experiments on cats ACTH facilitated the development of behavioral responses to gradually increasing electric stimulation of the medial hypothalamus, hippocampus and the midbrain reticular formation as well as potentiated the reticulo-hypothalamic influence. The effect of hydrocortisone was opposite. The reciprocal reticular and hormonal influences on the basal and anterior amygdala were revealed as well as some hormonal changes due to unspecific thalamic effects upon the limbic structures. The revealed systemic hormonal effect on the state and interaction of cerebral structures seems to be the base for integration of neural and hormonal mechanisms of some behavioral responses.

摘要

在对猫进行的慢性实验中,促肾上腺皮质激素(ACTH)促进了对内侧下丘脑、海马体和中脑网状结构逐渐增强的电刺激所产生的行为反应的发展,同时增强了网状结构-下丘脑的影响。氢化可的松的作用则相反。还揭示了网状结构与激素对基底杏仁核和前杏仁核的相互影响,以及由于丘脑对边缘结构的非特异性作用而导致的一些激素变化。所揭示的全身性激素对脑结构状态和相互作用的影响似乎是某些行为反应的神经和激素机制整合的基础。

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Fiziol Zh SSSR Im I M Sechenova. 1978 Jan;64(1):10-7.
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