Anderson F A, Wheeler H B, Goldberg R J, Hosmer D W, Patwardhan N A, Jovanovic B, Forcier A, Dalen J E
Department of Surgery, University of Massachusetts Medical School, Worcester 01655.
Arch Intern Med. 1991 May;151(5):933-8.
A community-wide study was conducted in 16 short-stay hospitals in metropolitan Worcester, Mass, to examine the incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism in patients hospitalized between July 1, 1985, and December 31, 1986. The average annual incidence of deep vein thrombosis alone was 48 per 100,000, while the incidence of pulmonary embolism with or without deep vein thrombosis was 23 per 100,000. The incidence rates of deep vein thrombosis and pulmonary embolism increased exponentially with age. The in-hospital case-fatality rate of venous thromboembolism was 12%. Among patients discharged from the hospital, the long-term case-fatality rates were 19%, 25%, and 30% at 1, 2, and 3 years after hospital discharge. Extrapolation of the data from this population-based study suggests that there are approximately 170,000 new cases of clinically recognized venous thromboembolism in patients treated in short-stay hospitals in the United States each year, and 99,000 hospitalizations for recurrent disease. Because of the silent nature of this disease and the low rate of autopsy in the United States, the total incidence, prevalence, and mortality rates of venous thromboembolism remain elusive.
在马萨诸塞州伍斯特市的16家短期住院医院开展了一项全社区范围的研究，以调查1985年7月1日至1986年12月31日期间住院患者深静脉血栓形成和肺栓塞的发病率及病死率。仅深静脉血栓形成的年均发病率为每10万人48例，而伴有或不伴有深静脉血栓形成的肺栓塞发病率为每10万人23例。深静脉血栓形成和肺栓塞的发病率随年龄呈指数增长。静脉血栓栓塞的院内病死率为12%。在出院患者中，出院后1年、2年和3年的长期病死率分别为19%、25%和30%。基于该人群研究的数据推断表明，美国短期住院医院每年接受治疗的患者中，临床上确诊的静脉血栓栓塞新发病例约有17万例，因复发疾病住院的有9.9万例。由于这种疾病的隐匿性以及美国较低的尸检率，静脉血栓栓塞的总发病率、患病率和死亡率仍不明确。
