Donatelli M, Terrizzi C, Russo V, Bucalo M L, Scarpinato A, Verga S, Puglisi S, Miceli G, Iraci T, Bompiani G D
Cattedra di Clinica medica I, Università, Palermo.
Recenti Prog Med. 1991 Jan;82(1):1-3.
Forty obese subjects with normal glucose tolerance test (NGTT) thirteen diabetic obese subjects and sixteen normal subjects were studied to evaluate the possible interactions between beta-endorphin (B-Ep) and glucose homeostasis. On the basis of baseline B-Ep levels, two subgroups were selected: one group with normal mean values of B-Ep (7.02 +/- 0.59 pmol/l); another group with elevated mean values of B-Ep (18.95 +/- 1.52 pmol/l). No differences between these subgroups were found as regards body mass index (BMI), insulin and glucagon levels. Normal B-Ep values were found in diabetic obese subjects. No significant correlation was found between B-Ep and BMI, insulin or glucagon. Considering that B-Ep is involved in eating behavior and on the basis of our results, we suggest that elevated B-Ep levels can be found only in those obese NGTT subjects whose obesity is probably related to an abnormal modulation of food intake, such as hyperphagia.
对40名葡萄糖耐量试验（NGTT）正常的肥胖受试者、13名糖尿病肥胖受试者和16名正常受试者进行了研究，以评估β-内啡肽（B-Ep）与葡萄糖稳态之间可能的相互作用。根据基线B-Ep水平，选择了两个亚组：一组B-Ep平均值正常（7.02±0.59 pmol/l）；另一组B-Ep平均值升高（18.95±1.52 pmol/l）。在体重指数（BMI）、胰岛素和胰高血糖素水平方面，这些亚组之间未发现差异。糖尿病肥胖受试者中发现B-Ep值正常。未发现B-Ep与BMI、胰岛素或胰高血糖素之间存在显著相关性。鉴于B-Ep参与饮食行为，基于我们的研究结果，我们认为只有在那些肥胖的NGTT受试者中才能发现B-Ep水平升高，这些受试者的肥胖可能与食物摄入的异常调节有关，如食欲亢进。
