Ramsing M, Friedrich U, Henriques U V
Aarhus Universitet, Institut for Human Genetik.
Ugeskr Laeger. 1991 Apr 22;153(17):1196-9.
The results of systematic autopsies of 29 fetuses from a consecutive material consisting of 19 late spontaneous abortions and four induced abortions from the Department of Gynaecology and Obstetrics in the Municipal Hospital in Arhus are presented. Where the spontaneous abortions were concerned, a cause of the abortion was revealed in 15 out of 19 cases (79%). Infection caused eight abortions, pathological placental conditions caused four, umbilical cord complications one case, an IUD in utero one case and severe fetal malformations one case. Serious congenital malformations were present in six out of the total number of 29 fetuses (21%). The diagnoses could be established in five cases and the risk of recurrence could be assessed. Increased fetal pathological activity in the form of systemic fetal pathological examinations will result in improved genetic counselling, more certain prenatal diagnosis and improved understanding of the pathogenesis of congenital deformities.
本文呈现了对来自奥胡斯市立医院妇产科的29例胎儿进行系统尸检的结果,这些胎儿来自连续的样本,包括19例晚期自然流产和4例人工流产。在自然流产案例中,19例中有15例(79%)查明了流产原因。感染导致8例流产,病理性胎盘情况导致4例,脐带并发症1例,子宫内节育器1例,严重胎儿畸形1例。29例胎儿总数中有6例(21%)存在严重先天性畸形。5例能够确诊并评估复发风险。以系统性胎儿病理检查形式增加胎儿病理活动,将有助于改善遗传咨询、更准确的产前诊断以及增进对先天性畸形发病机制的理解。