INTRODUCTION

Abnormal results of visual evoked potentilas (VEP) are typical for demyelinating diseases of the central nervous system, including multiple sclerosis. Elongation of P100 latency was the most frquent finding and sometimes changes in the shape of VEP responses or decrease of the amplitudes were observed.

AIM OF THE STUDY

Results of VEP in children with multiple sclerosis.

MATERIAL AND METHODS

11 patients in the developmental age with multiple sclerosis were included, the age range was 13 to 17 years, 6 girls and 5 boys, hospitalized at Department of Pediatric Neurology Chair of Pediatric and Adolescent Neurology, Jagiellonian University in the years 2004-2009. The control group consisted of 11 children with analogous age range and sex distribution. VEP were recorded during monoocular visual stimulation with black and white checkerboard pattern reversal (pattern reversal VEP). The responses were recorded from three active electrodes O1, O2 and Oz (according to the international 10/20 electrode placement system). Latencies of maximum positive deflection P100, preceding N75 component and following N135 and amplitude of N75/P100 were analyzed.

RESULTS

Elongation of P100 latency in the examined group was statistically significant when compared with controls. Differences of N75/P100 amplitudes did not differ statistically between the groups.

CONCLUSIONS

VEP are one of the most important paraclinic tests used in diagnosis of MS in children.