Borglykke Anders, Pisinger Charlotta, Jørgensen Torben, Ibsen Hans
Research Centre for Prevention and Health, Glostrup University Hospital, Ndr. Ringvej 57, Building 84/85, DK-2600 Glostrup, Denmark.
Clin Respir J. 2008 Jul;2(3):158-65. doi: 10.1111/j.1752-699X.2008.00055.x.
Chronic obstructive pulmonary disease (COPD) is a major contributor to morbidity and mortality. Smoking is the leading cause of COPD. Results from randomised trials regarding smoking cessation in hospitalised patients with COPD are few.
To assess the effect of smoking cessation groups (SCG) in patients with COPD admitted to hospital.
Two hundred and twenty-three patients admitted to hospital were assigned to either a control group (n = 102) or an intervention group (n = 121) by matter of vacancy. The smokers in the intervention group were offered participation in an SCG. Smoking status and change in self-reported symptoms were assessed after 1 year. Smoking status was self-reported and verified with carbohemoglobin measurement. Survival and hospital admissions were assessed after 5 years through national registers.
Forty-eight patients participated in an SCG. After 1 year, 36 (30%) patients in the intervention group were abstinent compared with 13 (13%) patients in the control group [odds ratio (95% confidence interval): 2.83 (1.40-5.74)]. There was a significant difference between the intervention group and the control group regarding change in self-reported phlegm. There was a non-significant tendency towards better survival in the intervention group (50.4%) compared with the control group (43.1%). After 3 years, the intervention group had a significantly fewer total number of days admitted to hospital and number of days hospitalised with COPD.
This study shows that an intervention consisting of offering participation in an SCG to chronic patients makes it possible to obtain higher abstinence rates. Furthermore, this intervention showed impact on phlegm, survival and hospital readmissions.
慢性阻塞性肺疾病(COPD)是发病和死亡的主要原因。吸烟是COPD的主要病因。关于住院COPD患者戒烟的随机试验结果很少。
评估戒烟组(SCG)对住院COPD患者的影响。
223名住院患者根据空缺情况被分配到对照组(n = 102)或干预组(n = 121)。干预组中的吸烟者被邀请参加戒烟组。1年后评估吸烟状况和自我报告症状的变化。吸烟状况通过自我报告并经碳氧血红蛋白测量验证。5年后通过国家登记册评估生存率和住院情况。
48名患者参加了戒烟组。1年后,干预组中有36名(30%)患者戒烟,而对照组中有13名(13%)患者戒烟[优势比(95%置信区间):2.83(1.40 - 5.74)]。干预组和对照组在自我报告的痰液变化方面存在显著差异。与对照组(43.1%)相比,干预组有更好的生存趋势,但差异不显著(50.4%)。3年后,干预组的总住院天数和因COPD住院的天数明显减少。
本研究表明,对慢性病患者提供参加戒烟组的干预措施能够获得更高的戒烟率。此外,这种干预措施对痰液、生存率和再次入院有影响。