Department of Urology, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Arch Phys Med Rehabil. 2010 Mar;91(3):340-4. doi: 10.1016/j.apmr.2009.11.006.
To evaluate the effects of a single transrectal ultrasound (TRUS)-guided transperineal injection of botulinum toxin A (BTX-A) to the external urethral sphincter (EUS) for treating detrusor external sphincter dyssynergia (DESD).
Descriptive study.
Rehabilitation hospital affiliated with a medical university.
Patients (N=18) with suprasacral spinal cord injury who had DESD confirmed on video-urodynamic study.
A single dose of 100U BTX-A was applied into the EUS via TRUS-guided transperineal route injection.
Maximal detrusor pressure, detrusor leak-point pressure, integrated electromyography (iEMG), maximal pressure on static urethral pressure profilometry, and postvoiding residuals.
There were significant reductions in iEMG (P=.008) and static (P=.012) and dynamic urethral pressure (P=.023), but not in detrusor pressure and detrusor leak-point pressure after treatment. Postvoiding residuals also significantly decreased in the first and second month after treatment (P<.012).
TRUS-guided transperineal injection of BTX-A has beneficial effects in treating DESD.
评估单次经直肠超声（TRUS）引导下经会阴注射肉毒毒素 A（BTX-A）至尿道外括约肌（EUS）治疗逼尿肌外括约肌协同失调（DESD）的效果。
描述性研究。
医科大学附属医院康复医院。
经视频尿动力学研究证实患有骶上脊髓损伤并伴有 DESD 的患者（N=18）。
通过 TRUS 引导的经会阴途径注射，将 100U BTX-A 的单剂量应用于 EUS。
最大逼尿肌压力、逼尿肌漏点压力、整合肌电图（iEMG）、静态尿道压力描记术的最大压力和残余尿量。
治疗后 iEMG（P=.008）、静态（P=.012）和动态尿道压力（P=.023）显著降低，但逼尿肌压力和逼尿肌漏点压力无显著变化。治疗后第一个和第二个月残余尿量也显著减少（P<.012）。
TRUS 引导下经会阴注射 BTX-A 对治疗 DESD 具有有益效果。
Zotero 插件