接受替诺福韦治疗的患者的肾脏管状功能损害与更高的替诺福韦血浆浓度有关。

Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations.

机构信息

Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

出版信息

AIDS. 2010 Apr 24;24(7):1064-6. doi: 10.1097/QAD.0b013e32833202e2.

PMID:20299966

Abstract

Tenofovir (TFV) is a nucleotide analogue active against HIV and hepatitis B virus. Although TFV rarely affects the glomerular function, abnormalities in the kidney tubular function appear to be quite common. The relationship between TFV exposure and kidney tubular dysfunction (KTD) was examined prospectively in 92 HIV-infected individuals. Median TFV plasma trough concentration was higher in patients with KTD than in the rest (182 vs. 106 ng/ml; P = 0.001). This dose-dependent effect further supports an involvement of TFV in KTD.

摘要

替诺福韦（TFV）是一种抗 HIV 和乙型肝炎病毒的核苷酸类似物。尽管 TFV 很少影响肾小球功能，但肾小管功能异常似乎相当常见。前瞻性研究了 92 例 HIV 感染者中 TFV 暴露与肾小管功能障碍（KTD）的关系。KTD 患者的 TFV 血浆谷浓度中位数高于其他患者（182 与 106ng/ml；P=0.001）。这种剂量依赖性效应进一步支持 TFV 参与 KTD。