马凡综合征并精神分裂症：1 例病例报告及文献复习。
Marfan syndrome and schizophrenia: a case report and literature review.
机构信息
University of Washington Medical Center, Box 356560, Seattle, WA 98195-6560, USA.
出版信息
Gen Hosp Psychiatry. 2010 Mar-Apr;32(2):228.e9-228.e10. doi: 10.1016/j.genhosppsych.2009.04.010. Epub 2009 Jun 9.
Abstract
INTRODUCTION
Marfan Syndrome (MFS), a disease of microfibril dysfunction, has been associated with schizophrenia in multiple case reports.
CASE REPORT
We present one case and review the literature that suggests these conditions may share a common etiologic pathway.
DISCUSSION
A possible underlying mechanism of both schizophrenia and MFS is the abnormal expression of growth factors and signaling cascades.
CONCLUSION
MFS patients should be monitored for psychiatric symptoms and patients with signs of MFS should be referred for appropriate medical care. Also, by understanding shared mechanisms, we may develop better understanding and treatments.
摘要
简介
马凡综合征（MFS）是一种微纤维功能障碍疾病，在多项病例报告中与精神分裂症有关。
病例报告
我们报告了一例病例，并回顾了文献，表明这些情况可能存在共同的病因途径。
讨论
精神分裂症和 MFS 的一个可能潜在机制是生长因子和信号级联的异常表达。
结论
应监测 MFS 患者的精神症状，有 MFS 迹象的患者应转介接受适当的医疗护理。此外，通过了解共同的机制，我们可能会更好地理解和治疗这些疾病。
相似文献
1
Marfan syndrome and schizophrenia: a case report and literature review.
Gen Hosp Psychiatry. 2010 Mar-Apr;32(2):228.e9-228.e10. doi: 10.1016/j.genhosppsych.2009.04.010. Epub 2009 Jun 9.
2
3
Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome.
Int Heart J. 2013;54(1):23-6. doi: 10.1536/ihj.54.23.
4
Co-occurrence of Marfan syndrome and schizophrenia: what can be learned?
Eur J Med Genet. 2012 Apr;55(4):252-5. doi: 10.1016/j.ejmg.2012.02.005. Epub 2012 Feb 22.
5
Use of electroconvulsive therapy for schizophrenia with comorbid Marfan syndrome.
J ECT. 2009 Dec;25(4):276-7. doi: 10.1097/YCT.0b013e3181a09d69.
6
Marfan syndrome: a review of the literature and case report.
Spec Care Dentist. 2013 Sep-Oct;33(5):248-54. doi: 10.1111/scd.12018. Epub 2013 Feb 28.
7
Physical fitness in children with Marfan and Loeys-Dietz syndrome: associations between cardiovascular parameters, systemic manifestations, fatigue, and pain.
Eur J Pediatr. 2024 May;183(5):2421-2429. doi: 10.1007/s00431-024-05456-z. Epub 2024 Mar 11.
8
Cardiovascular characteristics in Marfan syndrome and their relation to the genotype.
Verh K Acad Geneeskd Belg. 2009;71(6):335-71.
9
Introduction.
Adv Exp Med Biol. 2014;802:1-3. doi: 10.1007/978-94-007-7893-1_1.
10
Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF-β Pathway Inhibition.
J Am Heart Assoc. 2025 May 6;14(9):e037826. doi: 10.1161/JAHA.124.037826. Epub 2025 Apr 16.
引用本文的文献
1
Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes.
Int J Mol Sci. 2021 Aug 31;22(17):9464. doi: 10.3390/ijms22179464.
2
The shock of the new: progress in schizophrenia genomics.
Curr Genomics. 2011 Nov;12(7):516-24. doi: 10.2174/138920211797904089.
3
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Eur Arch Psychiatry Clin Neurosci. 2012 Oct;262(7):565-77. doi: 10.1007/s00406-012-0306-y. Epub 2012 Mar 23.
本文引用的文献
1
Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia.
Pharmacol Ther. 2009 Jan;121(1):115-22. doi: 10.1016/j.pharmthera.2008.11.002. Epub 2008 Nov 20.
2
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
Science. 2008 Apr 25;320(5875):539-43. doi: 10.1126/science.1155174. Epub 2008 Mar 27.
3
Fibrillin-rich microfibrils - structural and instructive determinants of mammalian development and physiology.
Connect Tissue Res. 2008;49(1):1-6. doi: 10.1080/03008200701820708.
4
Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13.
Biol Psychiatry. 2008 Mar 15;63(6):594-601. doi: 10.1016/j.biopsych.2007.07.021. Epub 2007 Oct 24.
5
Marfan syndrome: clinical diagnosis and management.
Eur J Hum Genet. 2007 Jul;15(7):724-33. doi: 10.1038/sj.ejhg.5201851. Epub 2007 May 9.
6
The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene.
J Med Genet. 2007 Jul;44(7):472-7. doi: 10.1136/jmg.2006.048637. Epub 2007 Mar 16.
7
Psychiatric symptomatology of Lujan-Fryns syndrome: an X-linked syndrome displaying Marfanoid symptoms with autistic features, hyperactivity, shyness and schizophreniform symptoms.
Psychiatr Genet. 2005 Sep;15(3):229-31. doi: 10.1097/00041444-200509000-00016.
8
Association between psychiatric disorders and Marfan's syndrome in a large Sardinian family with a high prevalence of cardiac abnormalities.
Clin Cardiol. 1997 Mar;20(3):243-5. doi: 10.1002/clc.4960200311.
9
Revised diagnostic criteria for the Marfan syndrome.
Am J Med Genet. 1996 Apr 24;62(4):417-26. doi: 10.1002/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R.
10
Marfan's syndrome and schizophrenia: a case report.
Arch Gen Psychiatry. 1987 Feb;44(2):190-2. doi: 10.1001/archpsyc.1987.01800140102017.
Zotero 插件