结直肠癌脑转移中高度的染色体不稳定性。

High chromosomal instability in brain metastases of colorectal carcinoma.

作者信息

Gutenberg Angelika, Gerdes Jan S, Jung Klaus, Sander Björn, Gunawan Bastian, Bock Hans C, Liersch Torsten, Brück Wolfgang, Rohde Veit, Füzesi Laszlo

机构信息

Department of Neurosurgery, Georg-August-University, Göttingen, D-37099, Germany.

出版信息

Cancer Genet Cytogenet. 2010 Apr 1;198(1):47-51. doi: 10.1016/j.cancergencyto.2009.12.006.

DOI:10.1016/j.cancergencyto.2009.12.006

PMID:20303014

Abstract

Information on structural chromosomal changes in brain metastases (BM) of colorectal carcinoma (CRC) is very limited. Therapeutic and diagnostic strategies to reduce the risk of BM have potential impact on cancer mortality. By using comparative genomic hybridization, the primary CRC of 11 patients and their corresponding 13 BM were analyzed. BM showed significantly more mean chromosomal aberrations than the primary CRC (13.6+/-2.1 vs. 7.9+/-1.9, P=0.03), significantly more chromosomal gains (7.2+/-0.9 vs. 3.5+/-0.9, P=0.01), and tended to have also more losses (6.1+/-1.4 vs. 4.0+/-1.1, P=0.29). Changes that occurred significantly more often in BM than in primary CRC were gains of 8q, 12p, 12q, and 20p, as well as losses of 5q. BM of CRC show a significantly higher chromosomal instability in comparison to primary tumors. The prevalently altered genomic regions in the metastases of this study are likely to harbor genes that play an important role in the genesis of brain-specific metastasis.

摘要

关于结直肠癌（CRC）脑转移（BM）中染色体结构变化的信息非常有限。降低脑转移风险的治疗和诊断策略对癌症死亡率具有潜在影响。通过使用比较基因组杂交技术，对11例患者的原发性结直肠癌及其相应的13个脑转移瘤进行了分析。脑转移瘤显示出比原发性结直肠癌明显更多的平均染色体畸变（13.6±2.1对7.9±1.9，P = 0.03），明显更多的染色体增加（7.2±0.9对3.5±0.9，P = 0.01），并且也倾向于有更多的缺失（6.1±1.4对4.0±1.1，P = 0.29）。在脑转移瘤中比原发性结直肠癌更频繁发生的变化是8q、12p、12q和20p的增加，以及5q的缺失。与原发性肿瘤相比，结直肠癌的脑转移瘤显示出明显更高的染色体不稳定性。本研究中转移瘤中普遍改变的基因组区域可能含有在脑特异性转移发生中起重要作用的基因。