[减重手术后的可溶性细胞间黏附分子-1和C反应蛋白]
[Soluble intercellular adhesion molecule-1 and C reactive protein after bariatric surgery].
作者信息
Orea Soler Isabel, Illán Gómez Fátima, Gonzálvez Ortega Manuel, Alcaraz Tafalla M Soledad, Pérez Paredes Matías, Lozano Almela M Luisa, Pascual Saura M Herminia, Pascual Díaz Mercedes
机构信息
Sección de Endocrinología y Nutrición, Hospital General Universitario Morales Meseguer, Murcia, España.
出版信息
Endocrinol Nutr. 2010 Mar;57(3):90-4. doi: 10.1016/j.endonu.2010.01.008. Epub 2010 Mar 19.
BACKGROUND AND OBJECTIVES
Obesity is associated with a state of chronic low-grade inflammation. A causal association between inflammatory processes and atherogenesis has been proposed. The aim of this study was to evaluate changes in the proinflammatory profile of morbidly obese patients who underwent bariatric surgery. Serum C-reactive protein (CRP) and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations were measured before and after massive weight loss due to gastric bypass.
METHODS
In this prospective study we measured CRP and sICAM-1 concentrations in 50 morbidly obese patients (19 men and 31 women) at baseline and 3, 6 and 12 months after gastric bypass.
RESULTS
Body mass index (BMI), CRP, and sICAM-1 decreased significantly. BMI correlated with CRP but not with sICAM-1.
CONCLUSIONS
The improvement in vascular risk profile after weight loss in morbidly obese patients could be partially explained by changes in inflammatory status.
背景与目的
肥胖与慢性低度炎症状态相关。炎症过程与动脉粥样硬化之间的因果关系已被提出。本研究的目的是评估接受减肥手术的病态肥胖患者促炎谱的变化。在因胃旁路手术导致大量体重减轻之前和之后，测量血清C反应蛋白（CRP）和可溶性细胞间黏附分子-1（sICAM-1）浓度。
方法
在这项前瞻性研究中，我们在基线以及胃旁路手术后3、6和12个月测量了50例病态肥胖患者（19名男性和31名女性）的CRP和sICAM-1浓度。
结果
体重指数（BMI）、CRP和sICAM-1显著下降。BMI与CRP相关，但与sICAM-1无关。
结论
病态肥胖患者体重减轻后血管风险状况的改善可能部分归因于炎症状态的变化。
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