Howard Hughes Medical Institute, University of California at San Francisco, 94143, USA.
Cell. 2010 Mar 19;140(6):777-83. doi: 10.1016/j.cell.2010.03.004.
Studies of the initiation and maintenance of asthma and allergic inflammation implicate dysregulated interactions between mucosal epithelia and innate immune cells as the underlying cause of these disorders. The similarities of these responses with mucosal responses to parasitic intestinal worms may reveal pathways relevant to the perplexing rise of these chronic inflammatory disorders.
哮喘和过敏性炎症的发病和维持研究提示,黏膜上皮细胞和固有免疫细胞之间失调的相互作用是这些疾病的根本原因。这些反应与黏膜对肠道寄生虫的反应相似,这可能揭示了与这些慢性炎症性疾病令人费解的高发相关的途径。