健康受试者中小剂量 ACTH 试验中唾液皮质醇与计算得出的游离血浆皮质醇的比较。
Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects.
机构信息
Laboratory of Human Endocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia.
出版信息
Clin Biochem. 2010 Jun;43(9):764-7. doi: 10.1016/j.clinbiochem.2010.03.005. Epub 2010 Mar 19.
OBJECTIVES
To compare free plasma cortisol (FPC) with salivary and calculated cortisol.
DESIGN AND METHODS
FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women.
RESULTS
FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement.
CONCLUSIONS
FCIalb and salivary cortisol are preferred surrogates of FPC.
目的
比较游离血浆皮质醇（FPC）与唾液皮质醇和计算皮质醇。
设计与方法
在健康女性的重复小剂量 ACTH 试验中，测定游离血浆皮质醇、唾液皮质醇、游离皮质醇指数（FCI）、白蛋白衍生游离皮质醇指数（FCIalb）、Coolen 指数和 Dorin 指数。
结果
FPC 与替代物显著相关，与 FCIalb 和唾液皮质醇相关性最强。FPC 与唾液皮质醇的方法一致性最高。
结论
FCIalb 和唾液皮质醇是 FPC 的首选替代物。
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