儿童恶性肿瘤和感染的 T 细胞治疗。
T-cell-based therapies for malignancy and infection in childhood.
机构信息
Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates Street, Suite 1770, MC3-3320, Houston, TX 77030, USA.
出版信息
Pediatr Clin North Am. 2010 Feb;57(1):83-96. doi: 10.1016/j.pcl.2009.11.002.
One major advance in T-cell-based immunotherapy in the last 20 years has been the molecular definition of numerous viral and tumor antigens. Adoptive T-cell transfer has shown definite clinical benefit in the prophylaxis and treatment of viral infections that develop in pediatric patients after allogeneic transplant and in posttransplant lymphoproliferative disease associated with the Epstein-Barr virus. Developing adoptive T-cell therapies for other malignancies presents additional challenges. This article describes the recent advances in T-cell-based therapies for malignancy and infection in childhood and strategies to enhance the effector functions of T cells and optimize the cellular product, including gene modification and modulation of the host environment.
在过去的 20 年中，T 细胞为基础的免疫疗法的一个主要进展是对多种病毒和肿瘤抗原进行了分子定义。过继性 T 细胞转移在预防和治疗异基因移植后发生的病毒感染以及与 EBV 相关的移植后淋巴组织增生性疾病方面已显示出明确的临床益处。为其他恶性肿瘤开发过继性 T 细胞疗法带来了额外的挑战。本文描述了儿童恶性肿瘤和感染的 T 细胞为基础的治疗方法的最新进展，以及增强 T 细胞的效应功能和优化细胞产品的策略，包括基因修饰和宿主环境的调节。
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