Department of Public Health and General Practice, University of Otago, Christchurch, New Zealand.
J Affect Disord. 2010 Oct;126(1-2):65-74. doi: 10.1016/j.jad.2010.02.136. Epub 2010 Mar 21.
Rapid cycling bipolar disorder has been studied almost exclusively in clinical samples.
A national cross-sectional survey in 2003-2004 in New Zealand used the Composite International Diagnostic Interview (CIDI 3.0). Diagnosis was by DSM-IV. Depression severity was assessed with the Quick Inventory of Depressive Symptoms (QIDS) and role impairment using Sheehan Scales. Complex survey analyses compared percentages and means, and used logistic regression and discrete-time survival analyses. Frequent mood episodes (FMEs) in the past 12 months (4+) were used as an indicator of rapid cycling.
The lifetime prevalence of bipolar disorder (I + II) was 1.7%. Twelve-month prevalence was 1.0%: 0.3% with FME and 0.7% with No FME (1-3 episodes). Another 0.7% had no episodes in that period. Age of onset was earliest for FME (16.0 years versus 19.5 and 20.1, p<.05). In the past 12 months, weeks in episode, total days out of role and role impairment in the worst month were all worse for the FME group (p<.0001) but both the FME and No-FME groups experienced severe and impairing depression. Lifetime suicidal behaviours and comorbidity were high in all three bipolar groups but differed little between them. About three-quarters had ever received treatment but only half with twelve-month disorder made treatment contact.
Recall, not observation of episodes.
Even in the community the burden of bipolar disorder is high. Frequent mood episodes in bipolar disorder are associated with still more disruption of life than less frequent episodes. Treatment is underutilized and could moderate the distress and impairment experienced.
快速循环型双相障碍几乎仅在临床样本中进行研究。
2003-2004 年在新西兰进行的全国横断面调查使用了复合国际诊断访谈(CIDI 3.0)。诊断采用 DSM-IV 标准。抑郁严重程度采用快速抑郁症状清单(QIDS)和希恩量表评估。采用复杂调查分析比较百分比和平均值,并采用逻辑回归和离散时间生存分析。过去 12 个月(4+)频繁的情绪发作(FMEs)被用作快速循环的指标。
双相障碍(I+II)终身患病率为 1.7%。12 个月患病率为 1.0%:FME 为 0.3%,无 FME(1-3 次)为 0.7%。在那段时间内还有 0.7%的人没有发作。FME 的发病年龄最早(16.0 岁,而 FME 和无 FME 分别为 19.5 岁和 20.1 岁,p<.05)。在过去 12 个月中,FME 组的发作周数、总缺工天数和最差月的角色损伤程度均更差(p<.0001),但 FME 和无 FME 组均经历了严重和致残的抑郁。所有三组双相障碍患者的终生自杀行为和合并症均很高,但彼此之间差异不大。约有四分之三的人曾接受过治疗,但只有一半的 12 个月障碍患者接受过治疗。
回忆,而非发作的观察。
即使在社区中,双相障碍的负担也很高。双相障碍的频繁情绪发作与更频繁的发作相比,对生活的破坏更大。治疗利用率低,可以减轻患者所经历的痛苦和损伤。