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2
Factors associated with rapid cycling in bipolar I manic patients: findings from a French national study.双相 I 型躁狂患者快速循环的相关因素:一项法国全国性研究的结果。
CNS Spectr. 2008 Sep;13(9):780-7. doi: 10.1017/s1092852900013900.
3
Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence.双相情感障碍中重度情感发作后的残留症状恢复及发作快速复发/再发
Arch Gen Psychiatry. 2008 Apr;65(4):386-94. doi: 10.1001/archpsyc.65.4.386.
4
Rapid-cycling bipolar I disorder: course and treatment outcome of a large sample across Europe.快速循环型双相I型障碍:欧洲大样本的病程及治疗结果
J Psychiatr Res. 2008 Oct;42(13):1068-75. doi: 10.1016/j.jpsychires.2007.12.004. Epub 2008 Feb 8.
5
Cross-national prevalence and risk factors for suicidal ideation, plans and attempts.自杀意念、计划和企图的跨国患病率及风险因素。
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6
Rapid cycling bipolar disorder--diagnostic concepts.快速循环型双相情感障碍——诊断概念
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Lifetime prevalence and projected lifetime risk of DSM-IV disorders in Te Rau Hinengaro: the New Zealand Mental Health Survey.《特劳希内加罗地区精神疾病诊断与统计手册第四版(DSM-IV)障碍的终生患病率及终生患病风险预测:新西兰心理健康调查》
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Twelve-month and lifetime health service use in Te Rau Hinengaro: The New Zealand Mental Health Survey.《特劳希内加罗的十二个月及终生医疗服务使用情况:新西兰心理健康调查》
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Te Rau Hinengaro: the New Zealand Mental Health Survey: overview of methods and findings.《蒂劳·希内加罗:新西兰心理健康调查》:方法与结果概述
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新西兰精神健康调查中频繁出现心境发作的双相情感障碍。

Bipolar disorder with frequent mood episodes in the New Zealand Mental Health Survey.

机构信息

Department of Public Health and General Practice, University of Otago, Christchurch, New Zealand.

出版信息

J Affect Disord. 2010 Oct;126(1-2):65-74. doi: 10.1016/j.jad.2010.02.136. Epub 2010 Mar 21.

DOI:10.1016/j.jad.2010.02.136
PMID:20307906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2897902/
Abstract

BACKGROUND

Rapid cycling bipolar disorder has been studied almost exclusively in clinical samples.

METHODS

A national cross-sectional survey in 2003-2004 in New Zealand used the Composite International Diagnostic Interview (CIDI 3.0). Diagnosis was by DSM-IV. Depression severity was assessed with the Quick Inventory of Depressive Symptoms (QIDS) and role impairment using Sheehan Scales. Complex survey analyses compared percentages and means, and used logistic regression and discrete-time survival analyses. Frequent mood episodes (FMEs) in the past 12 months (4+) were used as an indicator of rapid cycling.

RESULTS

The lifetime prevalence of bipolar disorder (I + II) was 1.7%. Twelve-month prevalence was 1.0%: 0.3% with FME and 0.7% with No FME (1-3 episodes). Another 0.7% had no episodes in that period. Age of onset was earliest for FME (16.0 years versus 19.5 and 20.1, p<.05). In the past 12 months, weeks in episode, total days out of role and role impairment in the worst month were all worse for the FME group (p<.0001) but both the FME and No-FME groups experienced severe and impairing depression. Lifetime suicidal behaviours and comorbidity were high in all three bipolar groups but differed little between them. About three-quarters had ever received treatment but only half with twelve-month disorder made treatment contact.

LIMITATIONS

Recall, not observation of episodes.

CONCLUSIONS

Even in the community the burden of bipolar disorder is high. Frequent mood episodes in bipolar disorder are associated with still more disruption of life than less frequent episodes. Treatment is underutilized and could moderate the distress and impairment experienced.

摘要

背景

快速循环型双相障碍几乎仅在临床样本中进行研究。

方法

2003-2004 年在新西兰进行的全国横断面调查使用了复合国际诊断访谈(CIDI 3.0)。诊断采用 DSM-IV 标准。抑郁严重程度采用快速抑郁症状清单(QIDS)和希恩量表评估。采用复杂调查分析比较百分比和平均值,并采用逻辑回归和离散时间生存分析。过去 12 个月(4+)频繁的情绪发作(FMEs)被用作快速循环的指标。

结果

双相障碍(I+II)终身患病率为 1.7%。12 个月患病率为 1.0%:FME 为 0.3%,无 FME(1-3 次)为 0.7%。在那段时间内还有 0.7%的人没有发作。FME 的发病年龄最早(16.0 岁,而 FME 和无 FME 分别为 19.5 岁和 20.1 岁,p<.05)。在过去 12 个月中,FME 组的发作周数、总缺工天数和最差月的角色损伤程度均更差(p<.0001),但 FME 和无 FME 组均经历了严重和致残的抑郁。所有三组双相障碍患者的终生自杀行为和合并症均很高,但彼此之间差异不大。约有四分之三的人曾接受过治疗,但只有一半的 12 个月障碍患者接受过治疗。

局限性

回忆,而非发作的观察。

结论

即使在社区中,双相障碍的负担也很高。双相障碍的频繁情绪发作与更频繁的发作相比,对生活的破坏更大。治疗利用率低,可以减轻患者所经历的痛苦和损伤。