阻塞性睡眠呼吸暂停的病理生理学和遗传学。
Pathophysiology & genetics of obstructive sleep apnoea.
机构信息
Brigham & Women's Hospital, Division of Sleep Medicine, Sleep Disorders Program & Harvard Medical School Boston, MA, USA.
出版信息
Indian J Med Res. 2010 Feb;131:176-87.
Abstract
Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.
摘要
阻塞性睡眠呼吸暂停（OSA）是一种高发疾病，已被证实与神经认知和心血管后果有关。OSA 患者在睡眠期间经历咽气道反复狭窄或塌陷。这种疾病的病理生理学可能有多种因素导致，个体间差异较大。OSA 的重要危险因素包括肥胖、男性和年龄增长。然而，这些主要危险因素的机制尚不清楚。我们简要回顾了成人 OSA 发病机制的最新知识，并强调了遗传在影响关键 OSA 病理生理特征方面的潜在作用。
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