Wendel G D, Cox S M, Bawdon R E, Theriot S K, Heard M C, Nobles B J
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas.
Am J Obstet Gynecol. 1991 May;164(5 Pt 2):1390-6. doi: 10.1016/0002-9378(91)91479-g.
The object of this randomized study was to compare the safety and efficacy of oral ofloxacin, 400 mg twice daily for 10 days, versus intramuscular cefoxitin, 2 gm, plus oral probenecid, 1 gm, followed by oral doxycycline, 100 mg twice daily for 10 days, in the outpatient treatment of uncomplicated acute salpingitis. Thirty-eight women (53%) had Neisseria gonorrhoeae from their pretreatment endocervical or endometrial cultures, and 18 had Chlamydia trachomatis (25%). Thirty-five of 37 women (95%) treated with the ofloxacin regimen were clinically cured, and 34 of 35 (97%) were cured with the cefoxitin-doxycycline regimen (p = 0.52). One clinical failure occurred in each group with N. gonorrhoeae infection, and one failure occurred in the ofloxacin group because of side effects. The bacteriologic response for N. gonorrhoeae in both groups was 100%. The eradication of C. trachomatis was 100% (10/10) for the cefoxitin/doxycycline group and 86% (6/7) for ofloxacin. The side effects were similar in both groups of subjects. In this study both regimens were effective for the outpatient treatment of uncomplicated acute salpingitis.
这项随机研究的目的是比较口服氧氟沙星（每日两次，每次400毫克，共10天）与肌肉注射头孢西丁（2克）加口服丙磺舒（1克），随后口服多西环素（每日两次，每次100毫克，共10天）在门诊治疗单纯性急性输卵管炎中的安全性和有效性。38名女性（53%）在治疗前的宫颈或子宫内膜培养物中检测出淋病奈瑟菌，18名女性（25%）检测出沙眼衣原体。接受氧氟沙星治疗方案的37名女性中有35名（95%）临床治愈，接受头孢西丁-多西环素治疗方案的35名女性中有34名（97%）临床治愈（p = 0.52）。每组中各有1例淋病奈瑟菌感染临床治疗失败，氧氟沙星组有1例因副作用治疗失败。两组中淋病奈瑟菌的细菌学反应均为100%。头孢西丁/多西环素组沙眼衣原体的清除率为100%（10/10），氧氟沙星组为86%（6/7）。两组受试者的副作用相似。在本研究中，两种治疗方案对门诊治疗单纯性急性输卵管炎均有效。
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