Liang Xiayuan, Greffe Brian, Cook Bruce, Giller Roger, Graham Douglas K, McGranahan Amy N, Wang Michael
Department of Pathology, The Children's Hospital, Aurora, CO, USA.
Pediatr Dev Pathol. 2011 Jan-Feb;14(1):57-63. doi: 10.2350/09-10-0724-CR.1. Epub 2010 Mar 23.
Gray zone lymphomas are defined as lymphoid malignancies that cannot be reliably classified into a single distinct disease entity after all available morphologic, immunophenotypic, and molecular investigations have been performed. The 2008 World Health Organization Classification proposed 2 gray zone lesions: (1) B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma and (2) B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma. These gray zone lesions are rare, especially in pediatric patients, and create a great challenge to both pathologists and oncologists because this differential diagnosis has direct implications for management strategies. In this manuscript, we report 2 cases of pediatric patients with gray zone lymphoma and review clinicopathologic features, treatment options, and outcomes of this uncommon tumor.
灰色地带淋巴瘤被定义为在进行了所有可用的形态学、免疫表型和分子研究后，仍无法可靠地归类为单一明确疾病实体的淋巴系统恶性肿瘤。2008年世界卫生组织分类法提出了2种灰色地带病变：（1）无法分类的B细胞淋巴瘤，其特征介于弥漫性大B细胞淋巴瘤和伯基特淋巴瘤之间；（2）无法分类的B细胞淋巴瘤，其特征介于弥漫性大B细胞淋巴瘤和经典霍奇金淋巴瘤之间。这些灰色地带病变很罕见，尤其是在儿科患者中，对病理学家和肿瘤学家都构成了巨大挑战，因为这种鉴别诊断对治疗策略有直接影响。在本手稿中，我们报告了2例儿科灰色地带淋巴瘤患者，并回顾了这种罕见肿瘤的临床病理特征、治疗选择和预后情况。
