Institut Recherches Servier, Suresnes, France.
Pflugers Arch. 2010 May;459(6):941-50. doi: 10.1007/s00424-010-0812-6. Epub 2010 Mar 24.
In cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide. Endothelium-dependent contractions involve the activation of endothelial cyclooxygenases and the release of various prostanoids, which activate thromboxane prostanoid (TP) receptors of the underlying vascular smooth muscle. The stimulation of TP receptors elicits not only the contraction and the proliferation of vascular smooth muscle cells but also diverse physiological/pathophysiological reactions, including platelet aggregation and activation of endothelial inflammatory responses. TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation.
在心血管疾病和衰老过程中，内皮功能障碍部分归因于内皮衍生收缩因子的释放，这些因子抵消了一氧化氮的血管舒张作用。内皮依赖性收缩涉及内皮环氧化酶的激活和各种前列腺素的释放，这些前列腺素激活血管平滑肌下的血栓素前列腺素（TP）受体。TP 受体的刺激不仅引起血管平滑肌细胞的收缩和增殖，还引起多种生理/病理生理反应，包括血小板聚集和内皮炎症反应的激活。TP 受体拮抗剂可减少高血压和糖尿病等疾病中的内皮功能障碍，是有效的抗血栓形成药物，并可预防血管炎症。
