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骨骼肌细胞内钙离子信号转导:解码复杂信息。

Intracellular Ca2+ signaling in skeletal muscle: decoding a complex message.

机构信息

Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.

出版信息

Exerc Sport Sci Rev. 2010 Apr;38(2):76-85. doi: 10.1097/JES.0b013e3181d495d2.

Abstract

Intracellular calcium (Ca2+) plays an important role in regulating muscle force production, metabolism, and muscle gene expression. It is hypothesized that the precise pattern of Ca2+ oscillations, determined by the Ca2+ channels activated and the contributing Ca2+ pools, controls the coupling between neural activation, force production, cellular energetics, and gene expression. The physiological and cellular coordination between these events will be discussed.

摘要

细胞内钙离子(Ca2+)在调节肌肉力量产生、代谢和肌肉基因表达方面发挥着重要作用。据推测,Ca2+通道的激活和参与的 Ca2+池决定了 Ca2+振荡的精确模式,从而控制神经激活、力量产生、细胞能量学和基因表达之间的偶联。本文将讨论这些事件之间的生理和细胞协调性。

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