N-(5-氯-8-羟基-2-苯乙烯基喹啉-7-基)苯磺酰胺衍生物的设计、合成及抗 HIV 整合酶活性评价。
Design, synthesis and anti-HIV integrase evaluation of N-(5-chloro-8-hydroxy-2-styrylquinolin-7-yl)benzenesulfonamide derivatives.
机构信息
College of Life Science & Bioengineering, Beijing University of Technology, Beijing, China.
出版信息
Molecules. 2010 Mar 16;15(3):1903-17. doi: 10.3390/molecules15031903.
Abstract
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.
摘要
苯乙烯基喹啉衍生物被证实为 HIV-1 整合酶抑制剂。基于我们之前对一系列苯乙烯基喹啉衍生物的 CoMFA 分析，设计并合成了 N-[(2-取代苯乙烯基)-5-氯-8-羟基喹啉-7-基]-苯磺酰胺衍生物，并评估了它们可能的 HIV IN 抑制活性。
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