Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
Pediatr Allergy Immunol. 2010 Aug;21(5):852-8. doi: 10.1111/j.1399-3038.2010.01004.x. Epub 2010 Mar 19.
Recent studies suggest that patients with common variable immunodeficiency (CVID) and low numbers of switched memory B cells have lower IgG levels and higher rates of autoimmune disease, splenomegaly, and granulomatous disease; however, no prior literature has focused exclusively on pediatric cases. We examined the relationship between switched memory B cells and clinical and immunologic manifestations of CVID in a pediatric population. Forty-five patients were evaluated. Patients were categorized as Group I (<5 switched memory B cells/ml, n = 24) or Group II (> or =5 switched memory B cells/mL, n = 21). CD3(+) T-cell counts and CD19(+) B-cell levels were lower among Group I patients. Only those in Group I had meningitis, sepsis, bronchiectasis, granulomatous lung disease, autoimmune cytopenias, or hematologic malignancies. Segregation of pediatric patients into high risk (Group I) and average risk (Group II) may assist in targeting surveillance appropriately.
最近的研究表明，患有普通可变免疫缺陷症（CVID）且转换记忆 B 细胞数量较少的患者 IgG 水平较低，自身免疫性疾病、脾肿大和肉芽肿性疾病的发生率较高；然而，之前的文献并未专门针对儿科病例进行研究。我们研究了转换记忆 B 细胞与儿科人群 CVID 的临床和免疫表现之间的关系。共评估了 45 名患者。患者分为 I 组（<5 个转换记忆 B 细胞/ml，n=24）或 II 组（>=5 个转换记忆 B 细胞/ml，n=21）。I 组患者的 CD3(+) T 细胞计数和 CD19(+) B 细胞水平较低。只有 I 组患者患有脑膜炎、败血症、支气管扩张、肉芽肿性肺部疾病、自身免疫性血细胞减少症或血液系统恶性肿瘤。将儿科患者分为高危（I 组）和平均风险（II 组）有助于有针对性地进行监测。
