体外产生的次级效应T细胞对体内痘苗病毒感染的保护作用。
Protective activity of secondary effector T cells generated in vitro against ectromelia virus infection in vivo.
作者信息
Kees U, Blanden R V
出版信息
Clin Exp Immunol. 1977 Dec;30(3):338-46.
The anti-viral activity of secondary effector cells generated in vitro against ectromelia virus infection was investigated. Depending upon the order of administration of cells and virus, 2 X 10(6) cells significantly reduce virus titres in recipient mice. Mice injected with lymphocytic choriomeningitis (LCM) virus are not protected by secondary effector cells against ectromelia virus infection and vice versa. The cells conferring anti-viral activity are sensitive to anti-theta and complement treatment, and must share H-2K or H-2D region genes with the recipients in order for significant reduction of virus titres to occur. The possibility of exploiting this approach in clinical medicine by using T cell-mediated mechanisms against certain viral infections is briefly discussed.
研究了体外产生的次级效应细胞针对埃可病毒感染的抗病毒活性。根据细胞和病毒给药的顺序，2×10⁶个细胞可显著降低受体小鼠体内的病毒滴度。注射淋巴细胞性脉络丛脑膜炎（LCM）病毒的小鼠不会受到次级效应细胞的保护而免受埃可病毒感染，反之亦然。赋予抗病毒活性的细胞对抗θ和补体处理敏感，并且必须与受体共享H-2K或H-2D区域基因，才能显著降低病毒滴度。简要讨论了通过使用T细胞介导的机制对抗某些病毒感染在临床医学中利用这种方法的可能性。
Zotero 插件