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低场磁共振成像在诊断犬膝关节半月板撕裂中的价值:一项前瞻性研究,以关节镜检查作为金标准,评估自然发生的颅交叉韧带损伤的敏感性和特异性。

Value of low-field magnetic resonance imaging in diagnosing meniscal tears in the canine stifle: a prospective study evaluating sensitivity and specificity in naturally occurring cranial cruciate ligament deficiency with arthroscopy as the gold standard.

作者信息

Böttcher Peter, Brühschwein Andreas, Winkels Philipp, Werner Hinnerk, Ludewig Eberhard, Grevel Vera, Oechtering Gerhard

机构信息

Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany.

出版信息

Vet Surg. 2010 Apr;39(3):296-305. doi: 10.1111/j.1532-950X.2010.00650.x. Epub 2010 Mar 19.

Abstract

OBJECTIVE

To evaluate the sensitivity and specificity of low-field magnetic resonance imaging (lfMRI) for detection of meniscal tears in the canine stifle.

STUDY DESIGN

Double-blinded prospective clinical study.

ANIMALS

Forty-two consecutive stifles of dogs (>or=20 kg; n=34) with clinical and radiologic signs suspicious for cranial cruciate ligament (CCL) insufficiency.

METHODS

Each stifle had 7 predefined lfMRI sequences using a 0.5 T magnet with a human knee coil. After lfMRI, diagnostic arthroscopy was performed by 1 surgeon unaware of the MRI findings. After completion of the study MRI images were read by 1 investigator, unaware of the intraoperative findings.

RESULTS

At arthroscopy, 22 stifles had meniscal tears requiring subtotal meniscectomy. Of these only 14 were identified by lfMRI. Overall sensitivity and specificity of lfMRI for detection of meniscal tears were 0.64 (95% confidence interval [95% CI]=0.43, 0.80) and 0.90 (95% CI=0.70, 0.97), respectively. Positive and negative predictive values were 0.88 (95% CI=0.64, 0.97) and 0.69 (95% CI=0.50, 0.83), respectively. Neither the state of dislocation of vertical longitudinal tears nor the amount of CCL rupture had an influence on lfMRI accuracy (P=1.00).

CONCLUSION

lfMRI was of low diagnostic accuracy in detecting meniscal tears, when compared with arthroscopy. Especially negative lfMRI findings should be interpreted with caution.

CLINICAL RELEVANCE

When using lfMRI as a noninvasive preoperative screening tool for the diagnosis of meniscal tears, a high percentage of missed meniscal tears has to be expected.

摘要

目的

评估低场磁共振成像(lfMRI)检测犬膝关节半月板撕裂的敏感性和特异性。

研究设计

双盲前瞻性临床研究。

动物

42个连续的犬膝关节(体重≥20 kg;n = 34),伴有临床和放射学体征,怀疑颅交叉韧带(CCL)功能不全。

方法

每个膝关节使用0.5 T磁体和人体膝关节线圈进行7个预定义的lfMRI序列检查。lfMRI检查后,由1名不了解MRI结果的外科医生进行诊断性关节镜检查。研究完成后,由1名不了解术中结果的研究人员阅读MRI图像。

结果

在关节镜检查中,22个膝关节存在半月板撕裂,需要进行半月板次全切除术。其中只有14个通过lfMRI检测到。lfMRI检测半月板撕裂的总体敏感性和特异性分别为0.64(95%置信区间[95%CI]=0.43,0.80)和0.90(95%CI=0.70,0.97)。阳性和阴性预测值分别为0.88(95%CI=0.64,0.97)和0.69(95%CI=0.50,0.83)。垂直纵向撕裂的脱位状态和CCL破裂程度均对lfMRI准确性无影响(P = 1.00)。

结论

与关节镜检查相比,lfMRI在检测半月板撕裂方面诊断准确性较低。特别是lfMRI阴性结果应谨慎解读。

临床意义

当使用lfMRI作为诊断半月板撕裂的非侵入性术前筛查工具时,预计会有很高比例的半月板撕裂漏诊。

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