Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA.
Am J Kidney Dis. 2010 Jul;56(1):122-31. doi: 10.1053/j.ajkd.2009.12.034. Epub 2010 Mar 25.
The incidence rate of acute kidney injury (AKI) is highest in elderly patients, who make up an ever-growing segment of the population at large. AKI in these patients is associated with an increased risk of short- and long-term death and chronic kidney disease, including end-stage renal disease. Whether AKI in older individuals carries a larger relative risk for these outcomes compared with younger individuals is unclear at this time. Other domains, such as health-related quality of life, may be mildly impacted on after an episode of AKI. No effective therapies for AKI currently are available for widespread use. However, because the incidence of AKI is highest in the elderly and the phenotype is not discernibly different from AKI in all populations, future randomized controlled trials of interventions for AKI should be performed in the elderly population.
急性肾损伤(AKI)的发病率在老年患者中最高,而老年患者在总人口中所占的比例不断增加。这些患者的 AKI 与短期和长期死亡以及慢性肾脏病(包括终末期肾病)的风险增加相关。目前尚不清楚与年轻个体相比,老年个体的 AKI 是否具有更大的相对风险。其他方面,如健康相关的生活质量,在 AKI 发作后可能会受到轻微影响。目前尚无广泛应用的 AKI 有效治疗方法。然而,由于 AKI 的发病率在老年人中最高,并且其表型与所有人群的 AKI 没有明显区别,因此未来针对 AKI 的干预措施的随机对照试验应该在老年人群中进行。