基于天然产物的杀虫剂5. 新型4-脱氧鬼臼毒素4'-取代苯磺酸盐衍生物对粘虫的体内设计、半合成及杀虫活性
Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.
作者信息
Xu Hui, Wang Juan-Juan
机构信息
Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China.
出版信息
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2500-2. doi: 10.1016/j.bmcl.2010.02.108. Epub 2010 Mar 11.
In an attempt to find the effective phytopesticides, eight novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL. Among all of the tested analogs, compounds 5a, 5c, 5d, and 5h showed the higher insecticidal activity than 4-deoxypodophyllotoxin. Especially 5a exhibited the most potent insecticidal activity compared with toosendanin, a commercial insecticide derived from Melia azedarach.
为了寻找有效的植物源杀虫剂，合成了8种新型的4-脱氧鬼臼毒素的4'-取代苯磺酸盐衍生物，并以1mg/mL的浓度对粘虫Walker的三龄前幼虫进行了体内初步测试。在所有测试的类似物中，化合物5a、5c、5d和5h表现出比4-脱氧鬼臼毒素更高的杀虫活性。特别是与从苦楝中提取的商业杀虫剂川楝素相比，5a表现出最强的杀虫活性。
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