相似文献
1
The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function.
Blood. 2010 Jun 10;115(23):4910-3. doi: 10.1182/blood-2009-12-257949. Epub 2010 Mar 30.
2
Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF.
Blood. 2014 Apr 17;123(16):2585-92. doi: 10.1182/blood-2013-11-538173. Epub 2014 Feb 20.
3
N-linked glycan stabilization of the VWF A2 domain.
Blood. 2016 Mar 31;127(13):1711-8. doi: 10.1182/blood-2015-09-672014. Epub 2016 Jan 14.
4
Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11602-7. doi: 10.1073/pnas.1018559108. Epub 2011 Jun 24.
5
Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis.
J Thromb Haemost. 2009 Dec;7(12):2096-105. doi: 10.1111/j.1538-7836.2009.03640.x. Epub 2009 Oct 8.
6
The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.
Blood. 2015 Mar 19;125(12):1968-75. doi: 10.1182/blood-2014-08-594556. Epub 2015 Jan 6.
7
A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.
PLoS One. 2017 Nov 29;12(11):e0188405. doi: 10.1371/journal.pone.0188405. eCollection 2017.
8
Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease.
Thromb Haemost. 2006 Dec;96(6):717-24. doi: 10.1160/th06-08-0460.
9
Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.
Blood. 2006 Mar 15;107(6):2339-45. doi: 10.1182/blood-2005-04-1758. Epub 2005 Dec 1.
10
A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.
Blood. 2009 Sep 24;114(13):2819-28. doi: 10.1182/blood-2009-05-224915. Epub 2009 Jul 8.
引用本文的文献
1
Open or closed? Understanding the molecular mechanisms and clinical implications of ADAMTS13's conformation.
Hemasphere. 2025 Jul 27;9(7):e70189. doi: 10.1002/hem3.70189. eCollection 2025 Jul.
2
Removal of the vicinal disulfide enhances the platelet-capturing function of von Willebrand factor.
Blood. 2023 Mar 23;141(12):1469-1473. doi: 10.1182/blood.2022018803.
3
Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects.
Blood Adv. 2022 May 10;6(9):2908-2919. doi: 10.1182/bloodadvances.2021005928.
4
Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
Cell. 2021 Jan 7;184(1):194-206.e14. doi: 10.1016/j.cell.2020.11.038. Epub 2020 Dec 23.
5
Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.
J Thromb Haemost. 2020 Jun;18(6):1278-1290. doi: 10.1111/jth.14785. Epub 2020 Mar 30.
6
Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
Int J Mol Sci. 2019 Apr 16;20(8):1884. doi: 10.3390/ijms20081884.
7
Long-ranged Protein-glycan Interactions Stabilize von Willebrand Factor A2 Domain from Mechanical Unfolding.
Sci Rep. 2018 Oct 30;8(1):16017. doi: 10.1038/s41598-018-34374-y.
8
Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations.
PLoS One. 2018 Sep 17;13(9):e0203675. doi: 10.1371/journal.pone.0203675. eCollection 2018.
9
Enhanced activity of an ADAMTS-13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke.
J Thromb Haemost. 2018 Nov;16(11):2289-2299. doi: 10.1111/jth.14275. Epub 2018 Oct 24.
10
A new redox switch regulating von Willebrand factor activity.
J Thromb Haemost. 2018 Jul;16(7):1257-1258. doi: 10.1111/jth.14147. Epub 2018 May 30.
本文引用的文献
1
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.
Blood. 2010 Feb 25;115(8):1640-9. doi: 10.1182/blood-2009-06-229203. Epub 2009 Dec 23.
2
Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis.
J Thromb Haemost. 2009 Dec;7(12):2096-105. doi: 10.1111/j.1538-7836.2009.03640.x. Epub 2009 Oct 8.
3
A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.
Blood. 2009 Sep 24;114(13):2819-28. doi: 10.1182/blood-2009-05-224915. Epub 2009 Jul 8.
4
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor.
Science. 2009 Jun 5;324(5932):1330-4. doi: 10.1126/science.1170905.
5
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor.
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9226-31. doi: 10.1073/pnas.0903679106. Epub 2009 May 21.
6
Essential role of the disintegrin-like domain in ADAMTS13 function.
Blood. 2009 May 28;113(22):5609-16. doi: 10.1182/blood-2008-11-187914. Epub 2009 Feb 20.
7
N-linked glycosylation of VWF modulates its interaction with ADAMTS13.
Blood. 2008 Mar 15;111(6):3042-9. doi: 10.1182/blood-2007-06-095042. Epub 2007 Nov 1.
8
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19099-104. doi: 10.1073/pnas.0607264104. Epub 2006 Dec 4.
9
Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18470-4. doi: 10.1073/pnas.0609190103. Epub 2006 Nov 22.
10
ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
J Biol Chem. 2006 Jan 20;281(3):1555-63. doi: 10.1074/jbc.M508316200. Epub 2005 Oct 12.
Zotero 插件