Xiao Dong-sheng, Zhuang Ping, Li Jian-yu, Zhang Yu-qing, Li Yong-jie
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Diseases under Ministry of Education, Beijing 100053, China.
Zhonghua Yi Xue Za Zhi. 2010 Jan 19;90(3):173-7.
To explore the neuronal activity in globus pallidus internus in patients with Parkinson's disease (PD) and dystonia.
Thirteen patients with Parkinson's disease and eight with dystonia undergoing stereotactic surgery of globus pallidus internus were studied. Microrecording in globus pallidus internus and electromyography on contralateral limbs to surgery were simultaneously performed. Single unit analysis, interspike intervals (ISI) and coefficient of variation of ISI were performed. ANOVA and Student t-test were employed to compare neuronal firing in globus pallidus internus between two patient groups.
One hundred and eight neurons were identified from PD patients, including 19.4% tremor-related neuronal activity, 55.6% neurons with tonic firing and 25.0% neurons with irregular discharge. Further analysis revealed that neurons with tonic firing had a mean firing rate of (103.7 +/- 25.5) Hz; neurons with irregular discharge had a mean firing rate of (63.4 +/- 16.1) Hz. Forty-five neurons were identified from patients with dystonia, including 37.8% neurons with tonic firing and 62.2% neurons with irregular discharge. Further analysis showed that neurons with tonic firing had a mean firing rate of (50.2 +/- 19.1) Hz; neurons with irregular discharge had a mean firing rate of (28.5 +/- 10.5) Hz. ANOVA showed that a significance of firing rate of tonic firing and irregular discharge in globus pallidus internus was reached between two patient groups (P < 0.001). The mean firing rate of two patterns of neuronal activity in PD were significantly higher than those in dystonia (Bonferroni test, both P < 0.05).
The data support the current view that an increased neuronal firing rate in globus pallidus internus is associated with PD whereas a decreased neuronal firing rate is associated with dystonia.
探讨帕金森病（PD）和肌张力障碍患者苍白球内侧部的神经元活动。
对13例帕金森病患者和8例肌张力障碍患者进行苍白球内侧部立体定向手术研究。同时进行苍白球内侧部微记录和手术对侧肢体肌电图检查。进行单单位分析、峰间间期（ISI）及ISI变异系数分析。采用方差分析和Student t检验比较两组患者苍白球内侧部神经元放电情况。
从PD患者中识别出108个神经元，其中19.4%为震颤相关神经元活动，55.6%为紧张性放电神经元，25.0%为不规则放电神经元。进一步分析显示，紧张性放电神经元平均放电频率为（103.7±25.5）Hz；不规则放电神经元平均放电频率为（63.4±16.1）Hz。从肌张力障碍患者中识别出45个神经元，其中37.8%为紧张性放电神经元，62.2%为不规则放电神经元。进一步分析表明，紧张性放电神经元平均放电频率为（50.2±19.1）Hz；不规则放电神经元平均放电频率为（28.5±10.5）Hz。方差分析显示，两组患者苍白球内侧部紧张性放电和不规则放电的放电频率具有显著性差异（P<0.001）。PD患者两种神经元活动模式的平均放电频率显著高于肌张力障碍患者（Bonferroni检验，均P<0.05）。
数据支持目前的观点，即苍白球内侧部神经元放电频率增加与PD相关，而神经元放电频率降低与肌张力障碍相关。
