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英国急性上消化道出血内镜治疗管理:全国性审计结果。

Use of endoscopy for management of acute upper gastrointestinal bleeding in the UK: results of a nationwide audit.

机构信息

Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.

出版信息

Gut. 2010 Aug;59(8):1022-9. doi: 10.1136/gut.2008.174599. Epub 2010 Mar 31.

Abstract

OBJECTIVES

To examine the use of endoscopy in the UK for acute upper gastrointestinal bleeding (AUGIB) and compare with published standards. To assess the organisation of endoscopy services for AUGIB in the UK. To examine the relationship between outcomes and out of hours (OOH) service provision.

DESIGN

Multi-centre cross sectional clinical audit.

SETTING

All UK hospitals accepting admissions with AUGIB.

PATIENTS

All adults (>or=16 yrs) presenting with AUGIB between 1st May and 30th June 2007.

DATA

Collection A custom designed web-based reporting tool was used to collect data on patient characteristics, comorbidity and haemodynamic status at presentation to calculate the Rockall score, use and timing of endoscopy, treatment including endoscopic, rebleeding and in-hospital mortality. A mailed questionnaire was used to collect data on facilities and service organisation.

RESULTS

Data on 6750 patients (median age 68 years) were analysed from 208 hospitals. 74% underwent inpatient endoscopy; of these 50% took place within 24 h of presentation, 82% during normal working hours and 3% between midnight and 8 am. Of patients deemed high-risk (pre-endoscopy Rockall score >or=5) only 55% were endoscoped within 24 h and 14% waited >or=72 h for endoscopy. Lesions with a high risk of rebleeding were present in 28% of patients of whom 74% received endoscopic therapy. Further bleeding was evident in 13% and mortality in those endoscoped was 7.4% (95% CI 6.7% to 8.1%). In 52% of hospitals a consultant led out of hours (OOH) endoscopy rota existed; in these hospitals 20% of first endoscopies were performed OOH compared with 13% in those with no OOH rota and endoscopic therapy was more likely to be administered (25% vs 21% in hospitals with no OOH rota). The risk adjusted mortality ratio was higher (1.21, p=0.10, (95%CI 0.96 to 1.51)) in hospitals without such rotas.

CONCLUSIONS

This audit has found continuing delays in performing endoscopy after AUGIB and underutilisation of standard endoscopic therapy particularly for variceal bleeding. In hospitals with a formal OOH endoscopy rota patients received earlier endoscopy, were more likely to receive endoscopic therapy and may have a lower mortality.

摘要

目的

检查英国在急性上消化道出血(AUGIB)中使用内窥镜的情况,并与已发表的标准进行比较。评估英国 AUGIB 内镜服务的组织情况。检查结果与非工作时间(OOH)服务提供之间的关系。

设计

多中心横断面临床审计。

地点

所有接受 AUGIB 入院治疗的英国医院。

患者

所有 2007 年 5 月 1 日至 6 月 30 日期间出现 AUGIB 的>或=16 岁的成年人。

数据

收集使用定制的基于网络的报告工具收集有关患者特征,合并症和入院时血流动力学状态的数据,以计算 Rockall 评分,内镜检查的使用和时间,包括内镜在内的治疗,再出血和住院死亡率。使用邮寄问卷收集有关设施和服务组织的数据。

结果

从 208 家医院分析了 6750 名患者(中位年龄 68 岁)的数据。74%的患者接受了住院内镜检查;其中 50%在入院后 24 小时内进行,82%在正常工作时间内进行,3%在午夜至上午 8 点之间进行。在被认为高风险的患者(内镜前 Rockall 评分>或=5)中,只有 55%在 24 小时内进行了内镜检查,而 14%的患者等待>或=72 小时进行内镜检查。有 28%的患者存在再出血风险较高的病变,其中 74%接受了内镜治疗。进一步出血在 13%的患者中可见,接受内镜检查的患者死亡率为 7.4%(95%CI 6.7%至 8.1%)。在 52%的医院中,存在由顾问领导的非工作时间(OOH)内镜轮班;在这些医院中,20%的首次内镜检查是在 OOH 期间进行的,而在没有 OOH 轮班的医院中则为 13%,并且更有可能进行内镜治疗(在没有 OOH 轮班的医院中为 25%,而在没有 OOH 轮班的医院中为 21%)。没有这些轮班的医院的风险调整死亡率更高(1.21,p=0.10,(95%CI 0.96 至 1.51))。

结论

该审核发现,AUGIB 后进行内镜检查的时间继续延迟,并且标准内镜治疗的使用率较低,尤其是对于静脉曲张出血。在有正式 OOH 内镜轮班的医院中,患者接受了更早的内镜检查,更有可能接受内镜治疗,并且死亡率可能较低。

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