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成人特定语言障碍的临床标志物的识别。

Identification of clinical markers of specific language impairment in adults.

机构信息

The Pennsylvania State University, University Park, PA 16802, USA.

出版信息

J Speech Lang Hear Res. 2010 Apr;53(2):414-29. doi: 10.1044/1092-4388(2009/08-0016).

Abstract

PURPOSE

To investigate the usefulness of 3 tasks known to be effective diagnostic clinical markers of specific language impairment (SLI) in children: (a) nonword repetition, (b) sentence repetition, and (c) grammaticality judgments of finiteness marking.

METHOD

Two groups of young adults, 13 with SLI and 18 with typical language, completed 3 experimental tasks: (a) nonword repetition, (b) sentence repetition, and (c) grammaticality judgments of sentences that were either correct or contained an omitted finiteness marker, an overt agreement error, or an omitted progressive -ing. Analyses included receiver operating characteristic curve analyses and computation of likelihood ratios associated with the use of each task as a clinical marker for SLI, as well as development of a logistic regression model that used multiple tasks as predictors.

RESULTS

Each marker task significantly contributed to classification of adults as affected or unaffected by SLI, with moderate positive and negative likelihood ratios. A combination of the 3 marker tasks was the best predictor of affectedness status with moderate to large likelihood ratios.

CONCLUSIONS

The results suggest that SLI persists into adulthood and that effective clinical markers of this disorder are similar to those used to identify SLI in children. Refinement of these tasks to increase their likelihood ratios will improve their usefulness in diagnosing SLI in adults.

摘要

目的

研究在儿童中被证明是特定语言损伤(SLI)有效诊断临床标志物的 3 项任务的有用性:(a)非词重复,(b)句子重复,和(c)限定标记的语法判断。

方法

两组年轻成年人,13 名 SLI 患者和 18 名语言正常者完成了 3 项实验任务:(a)非词重复,(b)句子重复,以及(c)正确句子或包含省略限定标记、显性一致错误或省略进行式 -ing 的句子的语法判断。分析包括接收器操作特征曲线分析以及与使用每个任务作为 SLI 临床标志物相关的似然比的计算,以及使用多个任务作为预测因子的逻辑回归模型的开发。

结果

每个标志物任务都显著有助于将成年人分类为受 SLI 影响或不受 SLI 影响,具有中等阳性和阴性似然比。将 3 个标志物任务结合使用是受影响状态的最佳预测因子,具有中等至大的似然比。

结论

结果表明 SLI 持续到成年期,并且该障碍的有效临床标志物与用于识别儿童 SLI 的标志物相似。对这些任务进行细化以提高其似然比将提高它们在诊断成年 SLI 中的有用性。

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