内皮素对哺乳动物心室收缩性的变力作用。
Inotropic effects of endothelin on mammalian ventricular contractility.
作者信息
Endoh M, Takanashi M
机构信息
Department of Pharmacology, Yamagata University School of Medicine, Japan.
出版信息
Basic Res Cardiol. 1991;86 Suppl 1:173-8.
Endothelin-1 elicited a concentration-dependent positive inotropic effect on the isolated rabbit, guinea pig, and rat, but not on the dog ventricular myocardium. The duration of isometric contractions was prolonged by endothelin-1 in a concentration-dependent manner, mainly by prolongation of relaxation time. Phorbol 12,13-dibutyrate (PDBu) (a tumor-promoting phorbol ester) inhibited the positive inotropic effect of endothelin-1, as well as myocardial alpha 1-adrenoceptor stimulation at low concentrations (10(-9) mol/l and above) without (10(-8) mol/l) or less (10(-7) mol/l) affecting the basal force of contraction, and the positive inotropic effect of beta-adrenoceptor stimulation. The present findings indicate that endothelin elicits a positive inotropic effect on mammalian ventricular myocardium, the characteristics of which are very similar to those of myocardial alpha-adrenoceptor stimulation.
内皮素-1对离体兔、豚鼠和大鼠心室肌产生浓度依赖性正性肌力作用，但对犬心室肌无此作用。内皮素-1以浓度依赖性方式延长等长收缩持续时间，主要是通过延长舒张时间。佛波醇12,13 - 二丁酸酯（PDBu）（一种促癌佛波酯）在低浓度（10(-9)mol/L及以上）时抑制内皮素-1的正性肌力作用以及心肌α1 - 肾上腺素能受体刺激，在浓度为10(-8)mol/L时无影响，在浓度为10(-7)mol/L或更低时不影响基础收缩力以及β - 肾上腺素能受体刺激的正性肌力作用。本研究结果表明，内皮素对哺乳动物心室肌产生正性肌力作用，其特征与心肌α - 肾上腺素能受体刺激的特征非常相似。
Zotero 插件