Division of Hematopathology, Mayo Clinic, 200 1(st) Street SW, Hilton 8200, Rochester, MN 55905, USA.
Leuk Res. 2010 Sep;34(9):1235-8. doi: 10.1016/j.leukres.2010.03.020. Epub 2010 Apr 1.
CD5 positivity in B-cell lymphoproliferative disorders (LPD) is usually considered characteristic of either chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL). However, other neoplastic B-LPDs may express CD5, albeit infrequently. In this study we have reviewed the tissue pathology of CD5+ B-LPDs that do not fulfill diagnostic criteria for CLL or MCL on flow cytometric studies of peripheral blood or bone marrow. Our results indicate that although CD5 positivity is most commonly associated with CLL and MCL, a significant minority of cases do not fall into these two categories. Phenotypically unusual CLL, marginal zone lymphoma and lymphoplasmacytic lymphoma were the most common diagnoses in this group of patients. Applying strict flow cytometry criteria, using genetic studies, and deferring to a lymph node/tissue diagnosis in non-classical cases are critical for accurate diagnosis and classification of CD5+ B-cell LPD.
CD5 阳性在 B 细胞淋巴增殖性疾病(LPD)中通常被认为是慢性淋巴细胞白血病(CLL)或套细胞淋巴瘤(MCL)的特征。然而,其他肿瘤性 B-LPD 也可能表达 CD5,尽管很少见。在这项研究中,我们回顾了流式细胞术研究外周血或骨髓未满足 CLL 或 MCL 诊断标准的 CD5+B-LPD 的组织病理学。我们的结果表明,虽然 CD5 阳性最常与 CLL 和 MCL 相关,但少数病例不属于这两种类型。表型异常的 CLL、边缘区淋巴瘤和淋巴浆细胞淋巴瘤是该组患者中最常见的诊断。应用严格的流式细胞术标准,结合遗传学研究,并在非典型病例中依赖淋巴结/组织诊断,对于 CD5+B 细胞 LPD 的准确诊断和分类至关重要。