[一名乙肝表面抗原阴性/乙肝核心抗体阳性的B细胞非霍奇金淋巴瘤患者在接受利妥昔单抗化疗时发生乙肝再激活]
[Hepatitis B reactivation in an HbsAg-negative/anti-HBc-positive patient with B-cell non-Hodgkin lymphoma receiving chemotherapy with rituximab].
作者信息
Muñoz Bertrán Eduardo, Pérez Ceballos Elena, Gómez Espín Rosa, Ortega González Isabel
机构信息
Sección de Aparato Digestivo, Hospital Morales Meseguer, Murcia, España.
出版信息
Gastroenterol Hepatol. 2010 May;33(5):377-81. doi: 10.1016/j.gastrohep.2010.01.010. Epub 2010 Apr 2.
Reactivation of hepatitis B virus infection in patients with resolved infection is rare and is usually associated with immunosuppressive therapy. Morbidity and mortality are high. Some cases of hepatitis B reactivation associated with the use of rituximab have previously been published. We present the case of a patient with B-cell non-Hodgkin lymphoma receiving combination chemotherapy with rituximab who showed hepatitis B reactivation followed by liver failure. The most recent literature on this topic is reviewed and discussed.
已治愈的乙肝病毒感染患者中，乙肝病毒再激活情况罕见，通常与免疫抑制治疗有关。发病率和死亡率很高。此前已发表过一些与使用利妥昔单抗相关的乙肝再激活病例。我们报告了1例接受利妥昔单抗联合化疗的B细胞非霍奇金淋巴瘤患者出现乙肝再激活并继发肝衰竭的病例。并对该主题的最新文献进行了综述和讨论。
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