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Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.
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Preclinical evaluation of Amphihevir, a first-in-class clinical Hepatitis C virus NS4B inhibitor.
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Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.
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Chronic Hepatitis C Infection in Children: Current Treatment and New Therapies.
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Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein.
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Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.
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The interaction between the hepatitis C proteins NS4B and NS5A is involved in viral replication.
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本文引用的文献

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Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.
Expert Opin Ther Pat. 2009 Feb;19(2):145-64. doi: 10.1517/13543770802672598.
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Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B.
J Virol. 2009 Jun;83(12):6257-68. doi: 10.1128/JVI.02663-08. Epub 2009 Apr 8.
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New therapies for hepatitis C virus infection.
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The way forward in HCV treatment--finding the right path.
Nat Rev Drug Discov. 2007 Dec;6(12):991-1000. doi: 10.1038/nrd2411.
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A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication.
J Virol. 2007 Oct;81(20):11096-105. doi: 10.1128/JVI.01249-07. Epub 2007 Aug 8.
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Replication of hepatitis C virus.
Nat Rev Microbiol. 2007 Jun;5(6):453-63. doi: 10.1038/nrmicro1645. Epub 2007 May 8.
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Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein.
J Gen Virol. 2006 Nov;87(Pt 11):3263-3272. doi: 10.1099/vir.0.82211-0.
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Palmitoylation and polymerization of hepatitis C virus NS4B protein.
J Virol. 2006 Jun;80(12):6013-23. doi: 10.1128/JVI.00053-06.
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Global epidemiology of hepatitis C virus infection.
Lancet Infect Dis. 2005 Sep;5(9):558-67. doi: 10.1016/S1473-3099(05)70216-4.

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