注定肥胖。
Fingered for a fat fate.
机构信息
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Cell Metab. 2010 Apr 7;11(4):244-5. doi: 10.1016/j.cmet.2010.02.014.
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage. A recent report (Gupta et al., 2010) identifies the zinc finger protein Zfp423 as a determining factor in preadipocyte commitment.
前脂肪细胞向脂肪细胞的分化受核受体过氧化物酶体增殖物激活受体γ (PPARγ) 的控制，但对于间充质干细胞中决定脂肪细胞谱系的早期转录事件知之甚少。最近的一份报告(Gupta 等人，2010 年)确定锌指蛋白 Zfp423 是前脂肪细胞定向分化的决定因素。
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