铜配合物对蛋白酪氨酸磷酸酶 1B 的强效抑制作用：对生物体系中铜毒性的影响。
Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems.
机构信息
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, PR China.
出版信息
Chem Commun (Camb). 2010 May 28;46(20):3547-9. doi: 10.1039/b925603b. Epub 2010 Apr 9.
DOI:10.1039/b925603b
PMID:20383386
Abstract
A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.
摘要
一种新型双核铜配合物和几种 Cu-氨基酸配合物以亚微摩尔级别的浓度竞争性地抑制蛋白酪氨酸磷酸酶 1B，提示铜配合物可能通过抑制蛋白酪氨酸磷酸酶来干扰细胞信号通路。
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