Department of Urology, University Medical Center Groningen, Hanzeplein 1, P.O. box 30.001, 9700 RB, Groningen, The Netherlands.
World J Urol. 2010 Aug;28(4):439-44. doi: 10.1007/s00345-010-0546-2. Epub 2010 Apr 10.
To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region.
Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN cancer registry. All had a follow-up of at least 5 years. Logistic regression analysis on treatments as well as survival analysis was performed.
The treatments were radical cystectomy in 205/548 (37.5%) patients. TUR plus radiotherapy in 246 (44.9%) and palliation in 97 (17.7%). Multivariate analysis identified TNM stage (P < 0.0001) and age (P < 0.0001) as independent variables for cystectomy. Hospital type and year of diagnosis were not significant different between patients treated by cystectomy versus other type of treatment. TNM stage (P < 0.0001), age (P = 0.0043), and comorbidity (P = 0.0028) were independent variables for disease-specific survival (DSS) after cystectomy.
In the CCCN region, only 1/3 of patients with MIBC were treated with radical cystectomy. TNM stage and age were identified as main variables for the choice for cystectomy. TNM stage, age, and comorbidity were independent variables for disease-specific survival after cystectomy.
评估荷兰北部综合癌症中心（CCCN）地区肌层浸润性膀胱癌（MIBC）患者的治疗方法和生存情况。
回顾性队列分析。从 CCCN 癌症登记处收集了 1997 年至 2002 年间诊断为 MIBC 的 548 例患者的数据。所有患者的随访时间均至少为 5 年。对治疗方法进行逻辑回归分析，并进行生存分析。
205/548（37.5%）例患者接受根治性膀胱切除术，246（44.9%）例患者行 TUR 加放疗，97（17.7%）例患者行姑息治疗。多变量分析确定 TNM 分期（P < 0.0001）和年龄（P < 0.0001）是行膀胱切除术的独立变量。行膀胱切除术的患者与行其他治疗的患者在医院类型和诊断年份方面无显著差异。TNM 分期（P < 0.0001）、年龄（P = 0.0043）和合并症（P = 0.0028）是行膀胱切除术患者疾病特异性生存（DSS）的独立变量。
在 CCCN 地区，仅有 1/3的 MIBC 患者接受根治性膀胱切除术。TNM 分期和年龄是选择膀胱切除术的主要变量。TNM 分期、年龄和合并症是行膀胱切除术患者疾病特异性生存的独立变量。
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