山鸡椒根中的次生代谢产物及其抗结核活性。
Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity.
机构信息
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
出版信息
J Nat Prod. 2010 May 28;73(5):890-6. doi: 10.1021/np100022s.
Bioassay-guided fractionation of the roots of Litsea hypophaea led to the isolation of seven new butanolides, namely, litseakolides H-N (1-7), all with the 3R,4S configuration, as well as three new biarylpropanoids, hypophaone (8), hypophaol (9), and hypophane (10), and 15 known compounds. The structures of 1-10 were determined by means of spectroscopic analysis. Litseakolide L (5) and N-trans-feruloylmethoxytyramine (11) showed antitubercular activity against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 25 and 1.6 microg/mL, respectively.
生物测定指导下的 litsea hypophaea 根部分离得到了 7 个新的丁内酯，分别为 litseakolides H-N（1-7），均具有 3R,4S 构型，以及 3 个新的联苯丙醇，hypophaone（8）、hypophaol（9）和 hypophane（10），和 15 个已知化合物。通过光谱分析确定了 1-10 的结构。litseakolide L（5）和 N-反式-阿魏酰甲氧基酪胺（11）对结核分枝杆菌 H（37）Rv 株显示出抗结核活性，MIC 值分别为 25 和 1.6 μg/mL。
Zotero 插件