Universidad de Leon, Instituto de Biomedicina, Area de Farmacologia, 24071 Leon, Spain.
Expert Opin Drug Metab Toxicol. 2010 May;6(5):633-42. doi: 10.1517/17425251003674364.
Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic and pharmacodynamic features of this drug. Considering the pharmacokinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects.
This paper reviews the studies carried out evaluating the interaction between levodopa and dietary factors.
The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations.
An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optimal therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic metabolism, rapid absorption in the proximal small intestine and short plasma half-life. Major problems with levodopa treatment are the fluctuations in clinical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Studies of levodopa interactions are very important to improve patient response to this drug.
左旋多巴是治疗帕金森病最有效的药物，因此了解该药物的药代动力学和药效学特征非常重要。考虑到左旋多巴的药代动力学以及可以改变它的因素，对于临床医生在开具左旋多巴产品的处方时至关重要，以便最大限度地提高其治疗效果。
本文综述了评估左旋多巴与饮食因素相互作用的研究。
读者将更深入地了解可能影响左旋多巴药代动力学的不同饮食因素，从而了解在几种情况下使用这种药物获得的治疗反应。
了解任何药物的药代动力学对于建立其最佳治疗方案至关重要，但由于其广泛的预系统代谢、在近端小肠的快速吸收和短血浆半衰期，左旋多巴尤其如此。左旋多巴治疗的主要问题是晚期帕金森病患者临床反应的波动，有时与左旋多巴的外周药代动力学有关。研究左旋多巴的相互作用对于改善患者对这种药物的反应非常重要。
