RB 有什么特别之处？
What's so special about RB?
机构信息
Department of Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
出版信息
Cancer Cell. 2010 Apr 13;17(4):313-4. doi: 10.1016/j.ccr.2010.03.010.
Abstract
RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence.
摘要
RB、p107 和 p130 是高度相关的蛋白，每个蛋白都能调节细胞增殖。然而，只有 RB 在癌症中经常发生突变。在本期《癌细胞》杂志中，Chicas 等人为此难题提供了新的线索，明确了 RB 在促进细胞衰老方面具有“特殊的”、非冗余的作用。
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