Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Arthritis Res Ther. 2010;12 Suppl 1(Suppl 1):S4. doi: 10.1186/ar2885. Epub 2010 Apr 14.
Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems especially strong. In the group of disorders known as polymyositis, the study of blood samples suggests a potential role. It is unknown what drives the sustained presence of type 1 interferon-inducible molecules in these diseases, as the type 1 interferons themselves have not been specifically detected along with their downstream biomarkers. Therapeutic development for blockade of IFNα is in progress aided by the identification of blood genomic biomarkers.
最近的研究表明，1 型干扰素诱导的分子在某些形式的肌炎发病机制中起作用。对于皮肌炎，这些分子损伤肌纤维的证据似乎尤为有力。在被称为多发性肌炎的一组疾病中，对血液样本的研究表明了其潜在作用。目前尚不清楚是什么导致这些疾病中 1 型干扰素诱导分子持续存在，因为尚未特异性检测到 1 型干扰素及其下游生物标志物。通过鉴定血液基因组生物标志物，有助于 IFNα 阻断的治疗开发。
