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翼状胬肉结膜自体移植联合羊膜移植术后坏死性巩膜炎的成功治疗

Successful treatment of necrotizing scleritis after conjunctival autografting for pterygium with amniotic membrane transplantation.

作者信息

Karalezli Aylin, Kucukerdonmez Cem, Borazan Mehmet, Akova Yonca A

机构信息

Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey.

出版信息

Orbit. 2010 Apr;29(2):88-90. doi: 10.3109/01676830903297563.

Abstract

PURPOSE

To report a case of necrotizing scleritis after pterygium surgery with conjunctival autografting (CA) and intraoperative Mitomycin C (MMC) and its treatment with amniotic membrane transplantation (AMT) and systemic steroid.

METHODS

A 41-year-old woman who had recurrent nasal pterygium underwent pterygium excision with CA and intraoperative MMC. Two weeks after surgery, graft necrosis and necrotizing scleritis associated with severe pain and irritation were observed on her operated eye.

RESULTS

Pulse steroid treatment (intravenous 1 g methylprednisolone for 3 days) was initiated and AMT was performed for ocular surface reconstruction. Over the next 2 weeks, the graft vascularization was complete and there was no complication which required further treatment.

CONCLUSIONS

Necrotizing scleritis is a rare complication of CA with MMC. Systemic steroid therapy is necessary for subsiding ocular inflammation and AMT can be performed for ocular surface reconstruction.

摘要

目的

报告1例翼状胬肉切除联合自体结膜移植术(CA)及术中使用丝裂霉素C(MMC)后发生坏死性巩膜炎的病例,以及采用羊膜移植术(AMT)和全身使用类固醇激素进行治疗的情况。

方法

一名41岁复发性鼻侧翼状胬肉女性患者接受了翼状胬肉切除联合CA及术中MMC治疗。术后两周,在其术眼观察到移植片坏死及伴有严重疼痛和刺激的坏死性巩膜炎。

结果

开始进行脉冲类固醇激素治疗(静脉注射1 g甲泼尼龙,连续3天),并实施AMT以重建眼表。在接下来的2周内,移植片血管化完成,未出现需要进一步治疗的并发症。

结论

坏死性巩膜炎是CA联合MMC治疗的一种罕见并发症。全身类固醇激素治疗对于减轻眼部炎症是必要的,AMT可用于眼表重建。

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