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大鼠窦房结中肌细胞关系的形态学分析

Morphological analysis of myocyte relationships in the sinoatrial node in rats.

作者信息

Sutiagin P V

机构信息

Department of Morphology, Medico-Biological Faculty, NI Pirogov Russian State Medical University, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2009 Nov;148(5):834-7. doi: 10.1007/s10517-010-0829-z.

Abstract

The presence of action potentials of working atrial cardiomyocytes among action potentials of true and latent pacemakers was revealed in the part of bidimentional maps of distribution of action potentials of sinoatrial node cells on the frontal surface of the right atrium under conditions of short-term culturing using intracellular glass microelectrodes. Detailed submicroscopical analysis of the node tissue was conducted. Sinoatrial node of rat heart consists of typical nodal cells and transition-type cardiomyocytes. Working atrial cardiomyocytes are absent in the tissue of the node. Action potentials of atrial cardiomyocytes among true and latent pacemakers in the course of electrophysiological study are recorded from cells of working myocardium of the thin subepicardial plate coverig the sinoatrial node.

摘要

在短期培养条件下,使用细胞内玻璃微电极,在右心房前表面窦房结细胞动作电位二维分布图的部分区域中,发现了工作心房心肌细胞的动作电位存在于真正和潜在起搏点的动作电位之中。对节点组织进行了详细的亚显微分析。大鼠心脏的窦房结由典型的节点细胞和过渡型心肌细胞组成。在节点组织中不存在工作心房心肌细胞。在电生理研究过程中,真正和潜在起搏点中的心房心肌细胞动作电位是从覆盖窦房结的薄心外膜下板的工作心肌细胞中记录到的。

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