MRI 上的肌肉萎缩与遗传性神经病变的手动肌力测试之间的相关性。

Correlation between muscle atrophy on MRI and manual strength testing in hereditary neuropathies.

机构信息

Department of Molecular Genetics, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

出版信息

J Clin Neurosci. 2010 Jul;17(7):874-8. doi: 10.1016/j.jocn.2009.11.006.

DOI:10.1016/j.jocn.2009.11.006

PMID:20399669

Abstract

MRI shows areas where muscle has been replaced by fat, a process which occurs in neuropathies. The purpose of this study was to investigate the usefulness of MRI in assessing disease severity in Charcot-Marie-Tooth (CMT) and hereditary motor neuropathy (HMN) compared to manual muscle testing (MMT). MRI and MMT correlated well (Spearman's rank correlation coefficient 0.910, 0.789-1.0). MRI was useful to document the extent and pattern of muscle atrophy and fat replacement and to determine the level of denervation. In addition, nerve length dependent denervation was confirmed in both CMT and HMN. MRI will be useful to confirm MMT findings and may be helpful for diagnosis of early or subclinical disease, as well as to further investigate the mechanisms of hereditary neuropathies.

摘要

MRI 显示肌肉已被脂肪替代的区域，这一过程发生在神经病变中。本研究旨在探讨 MRI 在评估肌萎缩性侧索硬化症（CMT）和遗传性运动神经病（HMN）疾病严重程度方面的有用性，与手动肌肉测试（MMT）相比。MRI 和 MMT 相关性良好（Spearman 秩相关系数 0.910，0.789-1.0）。MRI 可用于记录肌肉萎缩和脂肪替代的程度和模式，并确定去神经支配的程度。此外，在 CMT 和 HMN 中均证实了神经长度依赖性去神经支配。MRI 将有助于确认 MMT 的发现，并可能有助于诊断早期或亚临床疾病，以及进一步研究遗传性神经病的机制。