巨细胞病毒血症后与非霍奇金淋巴瘤相关的 AA 型淀粉样变性：尸检病例。

AA-type amyloidosis in association with non-Hodgkin's lymphoma following CMV viremia: Autopsy case.

机构信息

Department of Pathology, Kanto Medical Center NTT EC, Tokyo, Japan.

出版信息

Pathol Int. 2010 Mar;60(3):222-7. doi: 10.1111/j.1440-1827.2009.02505.x.

DOI:10.1111/j.1440-1827.2009.02505.x

PMID:20403049

Abstract

Amyloidosis in non-Hodgkin's lymphoma (NHL) is known to be of the AL type, and AA-type amyloidosis in NHL is extremely rare. Herein is reported an autopsy case of follicular lymphoma that transformed to diffuse large B-cell lymphoma (DLBCL) in a relapse associated with systemic AA amyloidosis. CMV infection in an immunocompromised state with chemotherapy against DLBCL may have been involved in amyloid accumulation. The serum amyloid A (SAA)1 gene polymorphism, SAA1.2/1.3, might have also been another factor in this case, considering the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.

摘要

非霍奇金淋巴瘤（NHL）中的淀粉样变性已知为 AL 型，而 NHL 中的 AA 型淀粉样变性极为罕见。本文报道了一例滤泡淋巴瘤病例，该患者在复发时发生弥漫性大 B 细胞淋巴瘤（DLBCL）转化，并伴有系统性 AA 淀粉样变性。DLBCL 化疗导致的免疫功能低下合并 CMV 感染可能与淀粉样物质的积累有关。考虑到日本类风湿关节炎患者发生 AA 淀粉样变性的风险，血清淀粉样蛋白 A（SAA）1 基因多态性 SAA1.2/1.3 也可能是该病例的另一个因素。